Emergency crews responded to the scene of a 20-vehicle crash on Friday afternoon, east of Brevort.
According to the Mackinac County Sheriff's Department, first responders are using four-wheel drive vehicles and snowmobiles to access the scene of the crash, which happened between 10 and 11 a.m. before the road was closed.
Police are reporting minor injuries at this time.
The Michigan Department of Transportation closed the stretch of US-2 from I-75 to M-77 on Friday morning due to white-out conditions. The highway was still closed as of Friday afternoon. Mackinac County Sheriff Scott Strait is urging motorists to stay off the roads.