Crews responded to a two vehicle crash Tuesday evening near Middle Inlet in Marinette County.
According to the Marinette County Sheriff's Department, a Sedan crossed the centerline of US-141 and struck an on-coming pickup truck head-on.
The driver of the Sedan was critically injured, according to police. The 22-year-old woman was taken to Bay Area Medical Center in Marinette, and then later flown to a Green Bay Hospital.
The 59-year-old woman driving the pickup truck was taken to the Bay Area Medical Center in Marinette to be treated for injuries.
The crash is still under investigation and an update on the condition of the drivers is not available at this time.